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COG-ACNS0332

Trial

Clinical Trial Title

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma

Trial Status

Open to Enrollment

Trial Type

Pediatric Cancer (Oncology)

Specific Condition

Medulloblastoma (High Risk)

Description

This randomized phase III trial studies different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma. Drugs used in chemotherapy, such as vincristine sulfate, cisplatin, cyclophosphamide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Isotretinoin may help chemotherapy work better by making tumor cells more sensitive to the drugs. Radiation therapy uses high-energy x-rays to kill tumor cells. Carboplatin may make tumor cells more sensitive to radiation therapy. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating brain tumors.

Eligibility Criteria

All patients must begin therapy within 31 days of diagnostic surgery

Age: >3 and <22 years of age at the time of diagnosis

Enrollment onto ALTE07C1 is strongly encourage (neurocognitive testing study)

Newly diagnosed, previously untreated medulloblastoma including pineoblastoma

Diffusely anaplastic medulloblastoma are eligible

All patients with M4 disease are not eligible

No previous chemotherapy or radiation therapy

Patients taking Accutane (Isotretinoin) for acne must discontinue drug use with this indication prior to enrollment

Corticosteroids should not be used during chemotherapy as an antiemetic because of their effect on the blood-brain barrier

No other experimental therapy is permitted while on study

Adequate kidney, liver, and bone marrow function

Principal Investigator Name

Janice Olson, MD

Contact Name

Children's Cancer and Blood Disorders Program

Phone

(503) 276-9300

Last Updated: Wednesday, January 27, 2021 11:41:12 AM