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Home > For Health Professionals > Legacy Research Institute > Research > Scientists > Claude F. Burgoyne, MD
Scientists
Emmanuel Akporiaye, PhD Michael Bottlang, PhD Claude F. Burgoyne, MD Megan Cahn, PhD Priya Chaudhary, PhD Shaban Demirel, OD, PhD Brad Fortune, OD, PhD Stuart Gardiner, PhD Soren Impey, PhD Robert Kinast, MD Kazuhiro Kurokawa, PhD Steve Mansberger, MD Danielle Osborne, PhD Adie Rae (Wilson-Poe), PhD Haiying Shen, MD, PhD Barbara A. Sorg, PhD Laura Villasana, PhD Hongli Yang, PhD LRI Publications Scientists

Claude F. Burgoyne, MD

Claude F. Burgoyne, M.D.

Senior Scientist and Van Buskirk Chair for Ophthalmic Research 
Director, Optic Nerve Head Research Laboratory
Devers Eye Institute, Discoveries in Sight Research Laboratories

Email: cfburgoyne@deverseye.org

CV (updated Nov 2022)  | Peer Reviewed Publications (Also see CV)
Optic Nerve Head Research Laboratory  |  Discoveries in Sight Laboratories  | Devers Eye Institute 
ORCID iD iconhttps://orcid.org/0000-0002-2765-4739

Short Bio:

Claude Burgoyne, MD is a Glaucoma clinician scientist, Van Buskirk Chair for Ophthalmic Research and Director of the Optic Nerve Head Research Laboratory at the Legacy Devers Eye Institute in Portland, Oregon. After an undergraduate Bachelor of Arts degree in Architecture and Medical School at the University of Minnesota, he pursued Ophthalmology residency training at the University of Pittsburgh and Glaucoma Fellowship training at the Wilmer Eye Institute at the Johns Hopkins Hospitals in Baltimore, MD. For twelve years he was Director of Glaucoma Services at the LSU Eye Center in New Orleans before moving to Devers in 2005. 

For the past 20 years his laboratory has been NIH funded to study the effects of aging and experimental glaucoma on the neural and connective tissues of the monkey optic nerve head within 3D histomorphometric reconstructions. This work now extends to studying the cell biology of connective tissue remodeling and axonal insult early in the disease. Building upon its 3D capabilities, his laboratory is also funded to use Optical Coherence Tomography (OCT) to phenotype the deep tissues of the monkey and human optic nerve head and peripapillary sclera. 

Dr. Burgoyne's honors include the International Glaucoma Review AIGS Award (2004), the Lewis Rudin Glaucoma Prize (2008), the Alcon Research Institute Award (2010); the American Glaucoma Society 2015 Clinician Scientist Lectureship, and the American Academy of Ophthalmology Achievement Award. 

He is an invited member of the Glaucoma Research Society and a Gold Fellow of the Association for Research in Vision and Ophthalmology, (ARVO), for which, he has previously served as Glaucoma Section Trustee and President.

Publication Highlights:

The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage.
Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT.
Prog Retin Eye Res. 2005 Jan;24(1):39-73.
https://www.ncbi.nlm.nih.gov/pubmed/15555526

The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.
Yang H, Reynaud J, Lockwood H, Williams G, Hardin C, Reyes L, Stowell C, Gardiner SK, Burgoyne CF.
Prog Retin Eye Res. 2017 Jul;59:1-52.
https://www.ncbi.nlm.nih.gov/pubmed/28300644

From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change.
Chauhan BC, Burgoyne CF.
Am J Ophthalmol 2013;156:218-227 e212.
https://www.ncbi.nlm.nih.gov/pubmed/23768651

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma.
Burgoyne CF.
Exp Eye Res. 2011 Aug;93(2):120-32
https://www.ncbi.nlm.nih.gov/pubmed/20849846

The morphological difference between glaucoma and other optic neuropathies.
Burgoyne CF.
J Neuroophthalmol. 2015 Sep;35 Suppl 1:S8-S21.
https://www.ncbi.nlm.nih.gov/pubmed/26274837

Research Interests:

  • Pathophysiology of glaucomatous optic nerve head damage
  • Optic nerve head biomechanics and blood flow
  • Optic nerve head aging
  • Optic nerve head imaging
  • Clinical examination of the optic nerve head tissues

Research Focus:

For the past 20 years the Devers Eye Institute Optic Nerve Head Research Laboratory (ONHRL) has been NIH funded to study the effects of aging and experimental glaucoma on the neural and connective tissues of the monkey optic nerve head within 3D histomorphometric reconstructions. This work now extends to studying the cell biology of connective tissue remodeling and axonal insult early in the disease. 

Building upon its 3D capabilities, the  ONHRL is also funded to use Optical Coherence Tomography (OCT) to phenotype the deep tissues of the monkey and human optic nerve head and peripapillary sclera. This work has contributed to a paradigm change in how human patients who have glaucoma or are at risk for developing the disease are imaged using OCT.