ADULT: ATTN FISH, PEDIATRIC: ATTN CYGEN
(13q14) - FOXO1A - Alveolar Rhabdomyosarcoma - ARMS
This probe detects translocations/variant rearrangements involving FOXO1 gene on chromosome 13 at 13q14 region. Chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) have been found to be specific for ARMS. As the prognosis of ARMS is worse, it is important to accurately distinguish between ARMS and ERMS (embryonal rhabdomyosarcomas). The distinction maybe difficult based on morphology alone.
Specimen Collection Requirements
Fluorescence In Situ Hybridization (FISH)
Professional interpretation provided by Cascade Pathology Services.
The partner chromosome of translocation can be determined by metaphase FISH, whenever applicable.
Saturday, January 18, 2020 01:08:50 AM
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