Patients must be enrolled on the COG AALL08B1 Classification Study prior to enrollment on AALL1131.
Age: >365 days and <31 Years of Age
White Blood Cell Count (WBC) Criteria:
- Age 1-9.99 years: WBC >50,000/uL
- Age 10-30.99 years: Any WBC
- Age 1-30.99 years: Any WBC with: a) testicular leukemia, b) CNS leukemia (CNS3), c) steroid pretreatment
High risk or standard risk ALL with central nervous system (CNS), testicular leukemia, and/or steroid pre-treatment
Standard Risk ALL patients enrolled on the COG AALL0932 (Standard Risk Study) and completed Induction treatment and been classified as High Risk or Very High Risk Newly diagnosed B-precursor ALL
Patients with Down Syndrome are also eligible
Patients must not have received any prior cytotoxic chemotherapy for the current diagnosis of ALL or any cancer diagnosed previously, with the exception of steroids and intrathecal cytarabine for the current diagnosis of ALL
Patients cannot have secondary ALL that developed after treatment of a prior malignancy with cytotoxic chemotherapy